Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements Rather than Mega-Dose Resveratrol Alone

According to the latest science, resveratrol pill users are best advised to consume modest doses of resveratrol plus an array of antioxidant molecules as typically provided in 3 to 5 glasses of aged, red wine, rather than resveratrol alone.

The most recent study shows mega-dose resveratrol alone fails to prolong the life of laboratory mice. In fact, mega-doses shortened the life of animals compared to a standard calorie diet with no resveratrol.
"While resveratrol an antioxidant molecule concentrated in red wine (about 1 milligram per glass), is touted for its health properties, partially explaining the French Paradox (why French wine drinkers have cardiac mortality rates 30% lower than North Americans despite their high-calorie, high-fat diets), it is not the sole molecule responsible for longevity," says Bill Sardi, spokesperson for Longevinex(R), a leading brand of resveratrol dietary supplement.

"The total array of red wine molecules found in the best red wine, about 60 milligrams per 5-ounce glass, or 180-300 milligrams in 3 to 5 glasses, is the suggested healthy dosage range," says Sardi.

Consistently, studies show modest doses of red wine lower mortality rates over abstention or over-consumption. [American Journal Epidemiology 1986 Sep; 124(3):481-9] Red wine pills offer the advantage of no alcohol, no calories or sulfite preservatives.

The negative effect upon lifespan with mega-dose resveratrol may emanate from over-inhibition of tumor necrosis factor (TNF), an inflammatory factor. Excessive TNF leads to inflammation, while too little impairs the immune system, says Sardi.

"We know that over-inhibition of TNF in humans increases the risk for lymphoma (cancer that originates in lymphocytes, a type of white blood cell)," says Sardi.
"When laboratory mice were given mega-dose resveratrol they did not live as long and largely succumbed to lymphoma. Resveratrol is a known TNF inhibitor," adds Sardi.